Developing optimal vaccination strategies for Rift Valley fever in East Africa

Rift Valley fever is a mosquito-borne viral zoonotic disease that affects sheep, goats, cattle and camels causing devastating losses, especially among pastoral communities that rely on livestock for their livelihoods. The disease occurs in explosive outbreaks following periods of above-normal and...

Improved vaccines for the control of East Coast fever in cattle in Africa

Due to high mortality and morbidity rates livestock diseases are an impediment to the livelihoods of poor farmers in Africa, who struggle to attain food and nutritional and economic security. Vaccines can alleviate such constraints as they are among the most successful disease interventions...

Applied genomics of tick vectors in relation to development of anti-tick vaccines and building research capacity in the eastern and central Africa

Ticks surpass all other arthropods in the number and variety of pathogens that they transmit to domestic animals, and rank second only to mosquitoes as vectors of human pathogens. A recent estimate indicates that globally livestock ticks alone are responsible for 14-17 billion dollars of economic...

Peste des petits ruminants (PPR): developing a pan African strategy for disease control

Africa Swine Fever Virus Genome Sequencing to underpin Control

This project will help to design incentives and other actions that will reduce the risks and impact of ASF, benefiting smallholder farmers in more than 20 countries in eastern, central, western and southern Africa. Currently there is no reliable data on total numbers of farmers affected in Africa;...

Providing proof of concept for the development of an inactivated vaccine for contagious bovine pleuropneumonia (CBPP)

Molecular epidemiology network for promotion and support of delivery of live vaccines against Theileria parva and Theileria annulata infection in Eastern and Northern Africa

Objectives: The general objective of the project is to ensure food security and to improve food safety by developing new and improving existing vaccination against bovine theileriosis caused by T. annulata and T. parva . The anticipated project aims to contribute to poverty alleviation by...

Accelerating CBPP research towards a better vaccine through application of synthetic biology

Objectives: Our long-term perspective is to apply key synthetic biology technologies to gain knowledge for vaccine development against diverse mycoplasma infections; the current project will show proof of principle. Two approaches will be pursued. 1. We propose to transfer the synthetic biology...

Enhanced control of CBPP through the development of an inactivated vaccine – proof of concept

Project goal and purpose A better vaccine to CBPP is the major stepping-stone for a successful eradication policy. Many attempts to improve the current live vaccine or to find protective antigens have failed. The main goal of this proposal is to deliver proof of concept for an inactivated vaccine.

BREAD: Toward development of a vaccine for contagious bovine pleuropneumonia

The purpose of this project is to improve cattle health on smallholder farms by advancing vaccine assessment technologies to characterize breed specific host responses to the foot-and-mouth disease virus and Theileria parva , the parasite that causes East Coast fever. It aims to use cutting edge...