Bridging Biobanking and Biomedical Research across Europe and Africa — B3Africa

ILRI biorepository

Services A platform for long term storage of materials. A platform for proper labelling of samples from the field. Support to projects in proper sample and data collection. Retrieving of samples and data in the repository. Source of liquid nitrogen to various projects. Current activities...

Comparative genome sequence analysis to identify disease and traits related genes under different selection pressures during chicken domestication

Objectives: • To identify candidate genes associated with disease resistance and economic traits through an analysis of signature of selection (SOS) between Asian and African lineage poultry. • To conduct statistical modeling of marker-assisted gene introgression (MAI) based on disease...

Production of disease tolerant cloned cattle in Africa

Objectives: 1. To reproduce herd through reproductive technique on cattle with disease tolerance in Africa 2. To maximize livestock production through establishment of embryo production with disease tolerance 3. To secure genetic diversity according to production of cloned animal with disease...

Molecular epidemiology network for promotion and support of delivery of live vaccines against Theileria parva and Theileria annulata infection in Eastern and Northern Africa

Objectives: The general objective of the project is to ensure food security and to improve food safety by developing new and improving existing vaccination against bovine theileriosis caused by T. annulata and T. parva . The anticipated project aims to contribute to poverty alleviation by...

Characterization of Theileria parva specific cytotoxic T. cells

Objectives: The overall objective of the project is to generate a profile of the specific CD8 cells, generated towards T. parva regarding cytokine expression, surface activation markers and memory markers from cattle immunized with the live vaccine. This profile can be used as a guideline for what...

Accelerating CBPP research towards a better vaccine through application of synthetic biology

Objectives: Our long-term perspective is to apply key synthetic biology technologies to gain knowledge for vaccine development against diverse mycoplasma infections; the current project will show proof of principle. Two approaches will be pursued. 1. We propose to transfer the synthetic biology...

Antimicrobials and improved diagnostics towards integrated control of CBPP

Objectives : 1. To elucidate the effector kinetics of oxytetracycline, tulathromycin and danofloxacin against the causal organism Mycoplasma mycoides mycoides Small Colony (MmmSC); 2. To model these data with available information on the distribution, metabolism and excretion of the drugs in cattle to develop rational candidate dosage strategies; 3. To evaluate these strategies in infection trials, monitoring effects on disease progression, transmission and development of resistance;

Enhanced control of CBPP through the development of an inactivated vaccine – proof of concept

Project goal and purpose A better vaccine to CBPP is the major stepping-stone for a successful eradication policy. Many attempts to improve the current live vaccine or to find protective antigens have failed. The main goal of this proposal is to deliver proof of concept for an inactivated vaccine.

Diagnostic and control tools and strategies for Taenia solium cysticercosis

The aim of this project is to make available and promote appropriate diagnostic and control tools and strategies for T. solium cysticercosis/taeniosis including the use of a user friendly “pen-side” diagnostic test, a vaccine and other options for control and prevention in targeted...